Once thing you start running into when you have many buffers is colliding names. For instance, if I open up two files ~/foo/test and ~/bar/test I would have two buffers named test<1> and test<2>. This depends on the version of Emacs, but is not very attractive. 

(require 'uniquify)
(setq uniquify-buffer-name-style 'post-forward
      uniquify-separator "::")

Now those two buffers would be named test::foo and test::bar, which I find more palatable.