One thing that started bugging me immediately upon using Gnus was the prompt for how many messages I wanted to load from my inbox when it had more than 200 messages in it. It turns out that this behaviour is controlled by gnus-large-newsgroup, described as:

The number of articles which indicates a large newsgroup.

If the number of articles in a newsgroup is greater than this value, confirmation is required for selecting the newsgroup.

If it is nil, no confirmation is required.

So let's stop this right now: 

(setq gnus-large-newsgroup nil)

Now I feel less like Gnus is judging me for the size of my inbox.